Patrolling monocytes control tumor metastasis to the lung

Simple item page
dc.citation.epage990en_US
dc.citation.issueNumber6263en_US
dc.citation.spage985en_US
dc.citation.volumeNumber350en_US
dc.contributor.authorHanna, R. N.en_US
dc.contributor.authorCekic, C.en_US
dc.contributor.authorSag, D.en_US
dc.contributor.authorTacke, R.en_US
dc.contributor.authorThomas, G. D.en_US
dc.contributor.authorNowyhed, H.en_US
dc.contributor.authorHerrley, E.en_US
dc.contributor.authorRasquinha, N.en_US
dc.contributor.authorMcArdle, S.en_US
dc.contributor.authorWu, R.en_US
dc.contributor.authorPeluso, E.en_US
dc.contributor.authorMetzger, D.en_US
dc.contributor.authorIchinose, H.en_US
dc.contributor.authorShaked, I.en_US
dc.contributor.authorChodaczek, G.en_US
dc.contributor.authorBiswas, S. K.en_US
dc.contributor.authorHedrick, C. C.en_US
dc.date.accessioned2016-02-08T10:59:32Z
dc.date.available2016-02-08T10:59:32Z
dc.date.issued2015en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.en_US
dc.identifier.doi10.1126/science.aac9407en_US
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/11693/26419
dc.language.isoEnglishen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.aac9407en_US
dc.source.titleScienceen_US
dc.subjectAnatomyen_US
dc.subjectBlooden_US
dc.subjectCanceren_US
dc.subjectCells and cell componentsen_US
dc.subjectDisease treatmenten_US
dc.subjectImmune systemen_US
dc.subjectRespiratory diseaseen_US
dc.subjectRodenten_US
dc.subjectTumoren_US
dc.subjectAnimal cellen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectArticleen_US
dc.subjectCancer controlen_US
dc.subjectCell interactionen_US
dc.subjectCell specificityen_US
dc.subjectCell transferen_US
dc.subjectControlled studyen_US
dc.subjectFemaleen_US
dc.subjectIn vivo studyen_US
dc.subjectLung metastasisen_US
dc.subjectMicrovasculatureen_US
dc.subjectMonocyteen_US
dc.subjectMouseen_US
dc.subjectNatural killer cellen_US
dc.subjectNonhumanen_US
dc.subjectPriority journalen_US
dc.subjectTumor cellen_US
dc.subjectTumor invasionen_US
dc.subjectAnimalen_US
dc.subjectExperimental neoplasmen_US
dc.subjectGeneticsen_US
dc.subjectImmunologyen_US
dc.subjectImmunosurveillanceen_US
dc.subjectImmunotherapyen_US
dc.subjectLung Neoplasmsen_US
dc.subjectMetastasisen_US
dc.subjectMonocyteen_US
dc.subjectMutant mouse strainen_US
dc.subjectProceduresen_US
dc.subjectSecondaryen_US
dc.subjectMusen_US
dc.subjectNr4a1 protein, mouseen_US
dc.subjectNuclear receptor Nur77en_US
dc.subjectAnimalsen_US
dc.subjectImmunologic Surveillanceen_US
dc.subjectImmunotherapyen_US
dc.subjectKiller Cells, Naturalen_US
dc.subjectLung Neoplasmsen_US
dc.subjectMiceen_US
dc.subjectMice, Mutant Strainsen_US
dc.subjectMonocytesen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectNeoplasm Metastasisen_US
dc.subjectNeoplasms, Experimentalen_US
dc.subjectNuclear Receptor Subfamily 4, Group A, Member 1en_US
dc.titlePatrolling monocytes control tumor metastasis to the lungen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Patrolling monocytes control tumor metastasis to the lung.pdf
Size:
886.91 KB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Department of Molecular Biology and Genetics