Patrolling monocytes control tumor metastasis to the lung

Date
2015
Authors
Hanna, R. N.
Cekic, C.
Sag, D.
Tacke, R.
Thomas, G. D.
Nowyhed, H.
Herrley, E.
Rasquinha, N.
McArdle, S.
Wu, R.
Advisor
Instructor
Source Title
Science
Print ISSN
0036-8075
Electronic ISSN
Publisher
American Association for the Advancement of Science
Volume
350
Issue
6263
Pages
985 - 990
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.

Course
Other identifiers
Book Title
Keywords
Anatomy, Blood, Cancer, Cells and cell components, Disease treatment, Immune system, Respiratory disease, Rodent, Tumor, Animal cell, Animal experiment, Animal model, Article, Cancer control, Cell interaction, Cell specificity, Cell transfer, Controlled study, Female, In vivo study, Lung metastasis, Microvasculature, Monocyte, Mouse, Natural killer cell, Nonhuman, Priority journal, Tumor cell, Tumor invasion, Animal, Experimental neoplasm, Genetics, Immunology, Immunosurveillance, Immunotherapy, Lung Neoplasms, Metastasis, Monocyte, Mutant mouse strain, Procedures, Secondary, Mus, Nr4a1 protein, mouse, Nuclear receptor Nur77, Animals, Immunologic Surveillance, Immunotherapy, Killer Cells, Natural, Lung Neoplasms, Mice, Mice, Mutant Strains, Monocytes, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Experimental, Nuclear Receptor Subfamily 4, Group A, Member 1
Citation
Published Version (Please cite this version)