CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer
Date
2021-04
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Cellular Oncology
Print ISSN
Electronic ISSN
1875-8606
Publisher
Springer
Volume
44
Issue
Pages
453 - 472
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Series
Abstract
Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.