Aptamer-based point-of-care devices: Emerging technologies and integration of computational methods

buir.contributor.authorAslan, Yusuf
buir.contributor.authorAtabay, Maryam
buir.contributor.authorChowdhury, Hussain Kawsar
buir.contributor.authorGöktürk, Ilgım
buir.contributor.authorİnci, Fatih
buir.contributor.orcidAtabay, Maryam|0000-0003-1930-1578
buir.contributor.orcidChowdhury, Hussain Kawsar|0000-0003-4569-8820
buir.contributor.orcidGöktürk, Ilgım|0000-0001-7292-7241
buir.contributor.orcidİnci, Fatih|0000-0002-9918-5038
dc.citation.epage34en_US
dc.citation.issueNumber5
dc.citation.spage[1]
dc.citation.volumeNumber13
dc.contributor.authorAslan, Yusuf
dc.contributor.authorAtabay, Maryam
dc.contributor.authorChowdhury, Hussain Kawsar
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorSaylan, Y.
dc.contributor.authorİnci, Fatih
dc.date.accessioned2024-03-19T08:21:09Z
dc.date.available2024-03-19T08:21:09Z
dc.date.issued2023-05-22
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)
dc.description.abstractRecent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices is currently limited due to obstacles associated with cost and production, impeding its widespread adoption. One promising alternative, on the other hand, is aptamer integration, i.e., short sequences of single-stranded DNA and RNA structures. The advantageous properties of these molecules are as follows: small molecular size, amenability to chemical modification, low- or nonimmunogenic characteristics, and their reproducibility within a short generation time. The utilization of these aforementioned features is critical in developing sensitive and portable POC systems. Furthermore, the deficiencies related to past experimental efforts to improve biosensor schematics, including the design of biorecognition elements, can be tackled with the integration of computational tools. These complementary tools enable the prediction of the reliability and functionality of the molecular structure of aptamers. In this review, we have overviewed the usage of aptamers in the development of novel and portable POC devices, in addition to highlighting the insights that simulations and other computational methods can provide into the use of aptamer modeling for POC integration.
dc.description.provenanceMade available in DSpace on 2024-03-19T08:21:09Z (GMT). No. of bitstreams: 1 Aptamer-Based_Point-of-Care_Devices_Emerging_Technologies_and_Integration_of_Computational_Methods.pdf: 5370699 bytes, checksum: cbe0f4da40a8f882d1578edb88b8cb46 (MD5) Previous issue date: 2023-05-22en
dc.identifier.doi10.3390/bios13050569
dc.identifier.eissn2079-6374
dc.identifier.urihttps://hdl.handle.net/11693/114946
dc.language.isoEnglish
dc.publisherMDPI
dc.relation.isversionofhttps://dx.doi.org/10.3390/bios13050569
dc.source.titleBiosensors
dc.subjectAptamer
dc.subjectAptasensor
dc.subjectBiosensor
dc.subjectComputational methods
dc.subjectNanomaterials
dc.subjectPoint-of-care
dc.titleAptamer-based point-of-care devices: Emerging technologies and integration of computational methods
dc.typeReview

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