An inductively coupled ultra-thin, flexible, and passive RF resonator for MRI marking and guiding purposes: Clinical feasibility

buir.contributor.authorDemir, Hilmi Volkan
buir.contributor.authorAtalar, Ergin
buir.contributor.orcidDemir, Hilmi Volkan|0000-0003-1793-112X
dc.citation.epage370en_US
dc.citation.issueNumber1en_US
dc.citation.spage361en_US
dc.citation.volumeNumber80en_US
dc.contributor.authorAlipour, A.en_US
dc.contributor.authorGökyar, S.en_US
dc.contributor.authorAlgın, O.en_US
dc.contributor.authorAtalar, Erginen_US
dc.contributor.authorDemir, Hilmi Volkanen_US
dc.date.accessioned2019-02-21T16:02:15Z
dc.date.available2019-02-21T16:02:15Z
dc.date.issued2018en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractPurpose: The purpose of this study is to develop a wireless, flexible, ultra-thin, and passive radiofrequency-based MRI resonant fiducial marker, and to validate its feasibility in a phantom model and several body regions. Methods: Standard microfabrication processing was used to fabricate the resonant marker. The proposed marker consists of two metal traces in the shape of a square with an edge length of 8 mm, with upper and lower traces connected to each other by a metalized via. A 3T MRI fiducial marking procedure was tested in phantom and ex vivo, and then the marker's performance was evaluated in an MRI experiment using humans. The radiofrequency safety was also tested using temperature sensors in the proximity of the resonator. Results: A flexible resonator with a thickness of 115 μm and a dimension of 8 × 8 mm was obtained. The experimental results in the phantom show that at low background flip angles (6-18°), the resonant marker enables precise and rapid visibility, with high marker-to-background contrast and signal-to-noise ratio improvement of greater than 10 in the vicinity of the marker. Temperature analysis showed a specific absorption ratio gain of 1.3. Clinical studies further showed a successful biopsy procedure using the fiducial marking functionality of our device. Conclusions: The ultra-thin and flexible structure of this wireless flexible radiofrequency resonant marker offers effective and safe MR visualization with high feasibility for anatomic marking and guiding at various regions of the body. Magn Reson Med 80:361-370, 2018.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:02:15Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.description.sponsorshipWe gratefully acknowledge Dr. Gamze Aykut, Department of Molecular Biology and Genetics, Bilkent University (Ankara, Turkey), and Dr. Cagdas Oto, Faculty of Veterinary Medicine, Ankara University (Ankara, Turkey), for their assistance in the ex vivo experiments, and the UMRAM staff for providing technical support.
dc.embargo.release2019-03-29en_US
dc.identifier.doi10.1002/mrm.26996
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttp://hdl.handle.net/11693/49984
dc.language.isoEnglish
dc.publisherJohn Wiley & Sons
dc.relation.isversionofhttps://doi.org/10.1002/mrm.26996
dc.relation.projectBilkent Üniversitesi - Ankara Universitesi
dc.source.titleMagnetic Resonance in Medicineen_US
dc.subjectInductive couplingen_US
dc.subjectMR-guided markeren_US
dc.subjectRF-passive resonatoren_US
dc.subjectThin-film structureen_US
dc.titleAn inductively coupled ultra-thin, flexible, and passive RF resonator for MRI marking and guiding purposes: Clinical feasibilityen_US
dc.typeArticleen_US

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