Expression of IFITM1 in chronic myeloid leukemia patients

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dc.citation.epage286en_US
dc.citation.issueNumber3en_US
dc.citation.spage283en_US
dc.citation.volumeNumber29en_US
dc.contributor.authorAkyerli, C. B.en_US
dc.contributor.authorBeksac, M.en_US
dc.contributor.authorHolko, M.en_US
dc.contributor.authorFrevel, M.en_US
dc.contributor.authorDalva, K.en_US
dc.contributor.authorÖzbek, U.en_US
dc.contributor.authorSoydan, E.en_US
dc.contributor.authorÖzcan, M.en_US
dc.contributor.authorÖzet, G.en_US
dc.contributor.authorİlhan, O.en_US
dc.contributor.authorGürman, G.en_US
dc.contributor.authorAkan, H.en_US
dc.contributor.authorWilliams, B. R. G.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2016-02-08T10:24:00Z
dc.date.available2016-02-08T10:24:00Z
dc.date.issued2005en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractWe investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:24:00Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2005en
dc.identifier.doi10.1016/j.leukres.2004.07.007en_US
dc.identifier.issn0145-2126
dc.identifier.urihttp://hdl.handle.net/11693/24093
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.leukres.2004.07.007en_US
dc.source.titleLeukemia Researchen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectGene expressionen_US
dc.subjectIFITM1en_US
dc.subjectRT-PCRen_US
dc.subjectInterferon induced transmembrane protein 1en_US
dc.subjectMembrane proteinen_US
dc.subjectUnclassified drugen_US
dc.subjectArticleen_US
dc.subjectBlooden_US
dc.subjectCell adhesionen_US
dc.subjectCell proliferationen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectControlled studyen_US
dc.subjectCorrelation analysisen_US
dc.subjectDisease classificationen_US
dc.subjectFemaleen_US
dc.subjectGene expressionen_US
dc.subjectHigh risk populationen_US
dc.subjectHumanen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectPredictionen_US
dc.subjectPriority journalen_US
dc.subjectPrognosisen_US
dc.subjectReal time polymerase chain reactionen_US
dc.subjectSignal transductionen_US
dc.subjectSurvivalen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectHumansen_US
dc.subjectLeukemia, Myeloid, Chronicen_US
dc.subjectMaleen_US
dc.subjectMembrane Proteinsen_US
dc.subjectMiddle Ageden_US
dc.subjectPrognosisen_US
dc.subjectReverse Transcriptase Polymerase Chain Reactionen_US
dc.subjectSurvival Analysisen_US
dc.subjectTumor Markers, Biologicalen_US
dc.titleExpression of IFITM1 in chronic myeloid leukemia patientsen_US
dc.typeArticleen_US

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