Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex

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buir.contributor.authorUyar, Tamer
buir.contributor.authorDurgun, Engin
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage1539en_US
dc.citation.issueNumber2en_US
dc.citation.spage1527en_US
dc.citation.volumeNumber53en_US
dc.contributor.authorAytaç, Zeynepen_US
dc.contributor.authorİpek, S.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2019-02-21T16:10:19Zen_US
dc.date.available2019-02-21T16:10:19Zen_US
dc.date.issued2018en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractQuercetin/gamma-cyclodextrin inclusion complex (quercetin/γ-CD-IC)-encapsulated electrospun zein nanofibers were designed as a quick and an efficient antioxidant nanofibrous material via electrospinning. Structural and thermal analyses along with the solubility enhancement as observed in phase-solubility diagram support the successful formation of the inclusion complexation between quercetin and γ-CD. The molar ratio of quercetin and γ-CD was found 1:1 in quercetin/γ-CD-IC which was confirmed with experimental (phase solubility and 1H-NMR) and computational modeling studies. Computational modeling was also useful to indicate that B orientation is more favorable when quercetin is forming host-guest inclusion complexation with γ-CD from the narrow rim. This result was also consistent with the calculations of the experimental studies performed by 1H-NMR. The successful electrospinning of zein nanofiber encapsulating quercetin/γ-CD-IC (zein-quercetin/γ-CD-IC-NF) yielded bead-free nanofiber morphology having 750 ± 255 nm fiber diameter. For comparative studies, pristine zein nanofibers (zein-NF, 695 ± 290 nm) and zein nanofibers encapsulating quercetin only (zein-quercetin-NF, 750 ± 310 nm) were also electrospun. The antioxidant (AO) characteristics of zein-quercetin/γ-CD-IC-NF were studied by the concentration-dependent AO activity tests.en_US
dc.description.provenanceMade available in DSpace on 2019-02-21T16:10:19Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en_US
dc.description.sponsorshipDr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK)-Turkey (Project # 111M459) for funding this research. Dr. Uyar and Dr. Durgun acknowledge The Turkish Academy of Sciences-Outstanding Young Scientists Award Program (TUBA-GEBIP) for partial funding of the research. Z. Aytac thanks to TUBITAK-BIDEB and TUBITAK (project # 111M459) for the PhD scholarship.en_US
dc.identifier.doi10.1007/s10853-017-1580-xen_US
dc.identifier.eissn1573-4803en_US
dc.identifier.issn0022-2461en_US
dc.identifier.urihttp://hdl.handle.net/11693/50500en_US
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttps://doi.org/10.1007/s10853-017-1580-xen_US
dc.relation.project111M459en_US
dc.source.titleJournal of Materials Scienceen_US
dc.titleAntioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complexen_US
dc.typeArticleen_US

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