Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex
buir.contributor.author | Uyar, Tamer | |
buir.contributor.author | Durgun, Engin | |
buir.contributor.orcid | Uyar, Tamer|0000-0002-3989-4481 | |
dc.citation.epage | 1539 | en_US |
dc.citation.issueNumber | 2 | en_US |
dc.citation.spage | 1527 | en_US |
dc.citation.volumeNumber | 53 | en_US |
dc.contributor.author | Aytaç, Zeynep | en_US |
dc.contributor.author | İpek, S. | en_US |
dc.contributor.author | Durgun, Engin | en_US |
dc.contributor.author | Uyar, Tamer | en_US |
dc.date.accessioned | 2019-02-21T16:10:19Z | en_US |
dc.date.available | 2019-02-21T16:10:19Z | en_US |
dc.date.issued | 2018 | en_US |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.department | Nanotechnology Research Center (NANOTAM) | en_US |
dc.description.abstract | Quercetin/gamma-cyclodextrin inclusion complex (quercetin/γ-CD-IC)-encapsulated electrospun zein nanofibers were designed as a quick and an efficient antioxidant nanofibrous material via electrospinning. Structural and thermal analyses along with the solubility enhancement as observed in phase-solubility diagram support the successful formation of the inclusion complexation between quercetin and γ-CD. The molar ratio of quercetin and γ-CD was found 1:1 in quercetin/γ-CD-IC which was confirmed with experimental (phase solubility and 1H-NMR) and computational modeling studies. Computational modeling was also useful to indicate that B orientation is more favorable when quercetin is forming host-guest inclusion complexation with γ-CD from the narrow rim. This result was also consistent with the calculations of the experimental studies performed by 1H-NMR. The successful electrospinning of zein nanofiber encapsulating quercetin/γ-CD-IC (zein-quercetin/γ-CD-IC-NF) yielded bead-free nanofiber morphology having 750 ± 255 nm fiber diameter. For comparative studies, pristine zein nanofibers (zein-NF, 695 ± 290 nm) and zein nanofibers encapsulating quercetin only (zein-quercetin-NF, 750 ± 310 nm) were also electrospun. The antioxidant (AO) characteristics of zein-quercetin/γ-CD-IC-NF were studied by the concentration-dependent AO activity tests. | en_US |
dc.description.provenance | Made available in DSpace on 2019-02-21T16:10:19Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018 | en_US |
dc.description.sponsorship | Dr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK)-Turkey (Project # 111M459) for funding this research. Dr. Uyar and Dr. Durgun acknowledge The Turkish Academy of Sciences-Outstanding Young Scientists Award Program (TUBA-GEBIP) for partial funding of the research. Z. Aytac thanks to TUBITAK-BIDEB and TUBITAK (project # 111M459) for the PhD scholarship. | en_US |
dc.identifier.doi | 10.1007/s10853-017-1580-x | en_US |
dc.identifier.eissn | 1573-4803 | en_US |
dc.identifier.issn | 0022-2461 | en_US |
dc.identifier.uri | http://hdl.handle.net/11693/50500 | en_US |
dc.language.iso | English | en_US |
dc.publisher | Springer | en_US |
dc.relation.isversionof | https://doi.org/10.1007/s10853-017-1580-x | en_US |
dc.relation.project | 111M459 | en_US |
dc.source.title | Journal of Materials Science | en_US |
dc.title | Antioxidant electrospun zein nanofibrous web encapsulating quercetin/cyclodextrin inclusion complex | en_US |
dc.type | Article | en_US |
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