Remote-controlled release of singlet oxygen by the plasmonic heating of endoperoxide-modified gold nanorods: towards a paradigm change in photodynamic therapy

Simple item page
dc.citation.epage3610en_US
dc.citation.issueNumber11en_US
dc.citation.spage3606en_US
dc.citation.volumeNumber55en_US
dc.contributor.authorKolemen, S.en_US
dc.contributor.authorOzdemir, T.en_US
dc.contributor.authorLee, D.en_US
dc.contributor.authorKim, G. M.en_US
dc.contributor.authorKaratas, T.en_US
dc.contributor.authorYoon, J.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2018-04-12T10:58:46Z
dc.date.available2018-04-12T10:58:46Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractThe photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them beyond the reach of most therapeutic protocols. More troublesome, photodynamic action generates acute hypoxia as the process itself diminishes cellular oxygen reserves, which makes it a self-limiting method. Herein, we describe a new concept that could eventually lead to a change in the 100 year old paradigm of photodynamic therapy and potentially offer solutions to some of the lingering problems. When gold nanorods with tethered endoperoxides are irradiated at 808 nm, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. We demonstrate that the amount of singlet oxygen produced in this way is sufficient for triggering apoptosis in cell cultures. EPT sees the light: When gold nanorods with tethered endoperoxides are irradiated with near-infrared light, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. The amount of singlet oxygen generated by these nanocomposites is sufficient for triggering apoptosis in cell cultures.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:58:46Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016en
dc.identifier.doi10.1002/anie.201510064en_US
dc.identifier.eissn1521-3773
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/11693/36968
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201510064en_US
dc.source.titleAngewandte Chemie - International Editionen_US
dc.subjectCell cultureen_US
dc.subjectCell deathen_US
dc.subjectDiseasesen_US
dc.subjectInfrared devicesen_US
dc.subjectNanorodsen_US
dc.subjectOxygenen_US
dc.subjectPeroxidesen_US
dc.subjectPhotosensitizersen_US
dc.subjectPlasmonsen_US
dc.subjectRemote controlen_US
dc.subjectTumorsen_US
dc.subjectEndoperoxidesen_US
dc.subjectMetastatic cancersen_US
dc.subjectNear infrared lighten_US
dc.subjectPhotodynamic actionen_US
dc.subjectPlasmonic heatingen_US
dc.subjectRemote controlled releaseen_US
dc.subjectSinglet oxygenen_US
dc.subjectTherapeutic protocolsen_US
dc.subjectPhotodynamic therapyen_US
dc.titleRemote-controlled release of singlet oxygen by the plasmonic heating of endoperoxide-modified gold nanorods: towards a paradigm change in photodynamic therapyen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods Towards a Paradigm Change in Photodynamic Therapy.pdf
Size:
3.59 MB
Format:
Adobe Portable Document Format
Description:
Full Printable Version
Download

Collections

Institute of Materials Science and Nanotechnology (UNAM)
Department of Chemistry