Menthol/cyclodextrin inclusion complex nanofibers: Enhanced water-solubility and high-temperature stability of menthol

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buir.contributor.authorUyar, Tamer
buir.contributor.authorDurgun, Engin
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage36en_US
dc.citation.spage27en_US
dc.citation.volumeNumber224en_US
dc.contributor.authorYildiz, Z. I.en_US
dc.contributor.authorCelebioglu A.en_US
dc.contributor.authorKilic, M. E.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2019-02-21T16:01:43Zen_US
dc.date.available2019-02-21T16:01:43Zen_US
dc.date.issued2018en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractCyclodextrins are capable of forming non-covalent host-guest inclusion complexation with variety of molecules in order to enhance water-solubility and thermal stability of such hydrophobic and volatile molecules. Menthol, an efficient antibacterial and flavour/fragrance agent, is used in various applications like food, pharmacy, cosmetics, however, its low water-solubility and high volatility somewhat limit its application. In this study, menthol/cyclodextrin-inclusion complex (menthol/CD-IC) was formed in highly concentrated aqueous solution by using hydroxypropyl-β-cyclodextrin (HPβCD) and hydroxypropyl-γ-cyclodextrin (HPγCD). The phase solubility studies and computational modeling studies revealed that menthol and these two CDs (HPβCD and HPγCD) formed stable inclusion complexes with the optimal molar ratio of 1:1 (menthol:CD) and inclusion complex formation enhanced the water-solubility of menthol. The electrospinning of nanofibers (NFs) from highly concentrated aqueous solutions (160%, w/v) of menthol/CD-IC was successfully performed without using additional fiber forming polymer and bead-free and uniform menthol/CD-IC NFs in the form of self-standing and flexible nanofibrous webs were produced. The initial molar ratio (1:1, menthol:CD) of the menthol/CD-IC in the solutions was mostly preserved in the menthol/CD-IC NFs (above 0.70:1.00, menthol:CD). The water-solubility of menthol was enhanced and menthol/CD-IC NFs have shown fast-dissolving character. The slow-release of menthol was achieved for menthol/CD-IC NFs, and the evaporation of menthol was shifted to much higher temperature (up to 275 °C) for menthol/CD-IC NFs which proved the high-temperature stability for menthol due to inclusion complexation.en_US
dc.description.provenanceMade available in DSpace on 2019-02-21T16:01:43Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en_US
dc.description.sponsorshipDr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK)-Turkey (Project # 213M185 ) for funding this research. Z. I. Yildiz thank to TUBITAK-BIDEB for the PhD scholarship.en_US
dc.embargo.release2019-05-01en_US
dc.identifier.doi10.1016/j.jfoodeng.2017.12.020en_US
dc.identifier.eissn1873-5770en_US
dc.identifier.issn0260-8774en_US
dc.identifier.urihttp://hdl.handle.net/11693/49905en_US
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jfoodeng.2017.12.020en_US
dc.relation.project213M185en_US
dc.source.titleJournal of Food Engineeringen_US
dc.subjectCyclodextrinsen_US
dc.subjectElectrospinningen_US
dc.subjectFast-dissolvingen_US
dc.subjectHigh-temperature stabilityen_US
dc.subjectMentholen_US
dc.subjectWater-solubilityen_US
dc.titleMenthol/cyclodextrin inclusion complex nanofibers: Enhanced water-solubility and high-temperature stability of mentholen_US
dc.typeArticleen_US

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