Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cells

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buir.contributor.authorSardan, Melis
buir.contributor.authorKilinc, Murat
buir.contributor.authorGenç, Rukan
buir.contributor.authorTekinay, Ayse B.
buir.contributor.authorGüler, Mustafa O.
dc.citation.epage283en_US
dc.citation.spage269en_US
dc.citation.volumeNumber166en_US
dc.contributor.authorSardan, Melisen_US
dc.contributor.authorKilinc, Muraten_US
dc.contributor.authorGenç, Rukanen_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2018-04-12T13:49:53Z
dc.date.available2018-04-12T13:49:53Z
dc.date.issued2013en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractLiposomes have been extensively used as effective nanocarriers, providing better solubility, higher stability and slower release of drugs compared to free drug administration. They are also preferred due to their nontoxic nature as well as their biodegradability and cell membrane mimicking abilities. In this study, we examined noncovalent integration of a cell penetrating arginine-rich peptide amphiphile into a liposomal formulation of negatively charged 1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (DOPG) phospholipids in the presence of cholesterol due to its amphipathic character. We studied changes in the physical characteristics (size, surface potential and membrane polarity) of the liposomal membrane, as well as in the encapsulation of hydrophilic and hydrophobic agents due to peptide amphiphile incorporation. The activities of peptide integrated liposomal systems as drug delivery agents were investigated by using anti-cancer drugs, doxorubicin-HCl and paclitaxel. Enhancement in liposomal uptake due to arginine-rich peptide integration, and enhanced efficacy of the drugs were observed with peptide functionalized liposomes compared to free drugs. © 2013 The Royal Society of Chemistry.en_US
dc.identifier.doi10.1039/c3fd00058cen_US
dc.identifier.issn1359-6640
dc.identifier.urihttp://hdl.handle.net/11693/38170
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c3fd00058cen_US
dc.source.titleFaraday Discussionsen_US
dc.titleCell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cellsen_US
dc.typeReviewen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Aysel Sabuncu Brain Research Center (BAM)