PEGylated calix[4]arene as a carrier for a Bodipy-based photosensitizer
Date
2014
Authors
Cakmak, Y.
Nalbantoglu, T.
Durgut, T.
Akkaya, E. U.
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Tetrahedron Letters
Print ISSN
0040-4039
Electronic ISSN
1873-3581
Publisher
Elsevier
Volume
55
Issue
2
Pages
538 - 540
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Series
Abstract
Heavy atom substituted Bodipy compounds, unlike the parent chromophore, undergo rapid intersystem crossing to generate singlet oxygen, which is the primary cytotoxic agent exploited in PDT. In this work, we show that an organic soluble calix[4]arene can be functionalized by Knoevenagel reaction and then converted into an amphiphilic photosensitizer in a few steps. In addition to generating a potentially useful photosensitizer, the sequence of reactions is the first use of a Bodipy dye as a chromophoric/fluorogenic label without the typical reactive functional groups.