Browsing by Subject "pKa"
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Item Open Access Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers(Royal Society of Chemistry, 2015) Erbas-Cakmak, S.; Cakmak, F. P.; Topel, S. D.; Uyar, T. B.; Akkaya, E. U.A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.