Browsing by Subject "Thiazolidine"
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Item Open Access A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells(Elsevier, 2012) Onen-Bayram, F. E.; Durmaz, I.; Scherman, D.; Herscovici, J.; Cetin Atalay, R.The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserved.