A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells

Date

2012

Authors

Onen-Bayram, F. E.
Durmaz, I.
Scherman, D.
Herscovici, J.
Cetin Atalay, R.

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Abstract

The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserved.

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Bioorganic and Medicinal Chemistry

Publisher

Elsevier

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Published Version (Please cite this version)

Language

English