Browsing by Subject "Mitochondrial carrier homolog 1"

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    Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease
    (Elsevier, 2013) Vural, B.; Şehitoğlu, E.; Çavuş, F.; Yalçınkaya, N.; Haytural, H.; Küçükerden, M.; Ulusoy, C.; Uğurel, E.; Turan, S.; Bulut, L.; Türkoğlu, R.; Shugaiv, E.; Kürtüncü, M.; Atakan, S.; Güre, A. O.; Gül, A.; Eraksoy, M.; Demir, G. A.; Tüzün, E.
    Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V.