Browsing by Subject "Carcinoma cell lines"

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Open Access
Carcinoma cell line discrimination in microscopic images using unbalanced wavelets
(IEEE, 2012-03) Keskin, Furkan; Suhre, Alexander; Erşahin, Tüli,; Çetin Atalay, Rengül; Çetin, A. Enis
Cancer cell lines are widely used for research purposes in laboratories all over the world. In this paper, we present a novel method for cancer cell line image classification, which is very costly by conventional methods. The aim is to automatically classify 14 different classes of cell lines including 7 classes of breast and 7 classes of liver cancer cells. Microscopic images containing irregular carcinoma cell patterns are represented by randomly selected subwindows which possibly correspond to foreground pixels. For each subwindow, a correlation descriptor utilizing the fractional unbalanced wavelet transform coefficients and several morphological attributes as pixel features is computed. Directionally selective textural features are preferred primarily because of their ability to characterize singularities at multiple orientations, which often arise in carcinoma cell lines. A Support Vector Machine (SVM) classifier with Radial Basis Function (RBF) kernel is employed for final classification. Over a dataset of 280 images, we achieved an accuracy of 88.2%, which outperforms the classical correlation based methods. © 2012 IEEE.
Open Access
Microscopic image classification via WT-based covariance descriptors using Kullback-Leibler distance
(IEEE, 2012) Keskin, Furkan; Çetin, A. Enis; Erşahin, Tülin; Çetin-Atalay, Rengül
In this paper, we present a novel method for classification of cancer cell line images using complex wavelet-based region covariance matrix descriptors. Microscopic images containing irregular carcinoma cell patterns are represented by randomly selected subwindows which possibly correspond to foreground pixels. For each subwindow, a new region descriptor utilizing the dual-tree complex wavelet transform coefficients as pixel features is computed. WT as a feature extraction tool is preferred primarily because of its ability to characterize singularities at multiple orientations, which often arise in carcinoma cell lines, and approximate shift invariance property. We propose new dissimilarity measures between covariance matrices based on Kullback-Leibler (KL) divergence and L 2-norm, which turn out to be as successful as the classical KL divergence, but with much less computational complexity. Experimental results demonstrate the effectiveness of the proposed image classification framework. The proposed algorithm outperforms the recently published eigenvalue-based Bayesian classification method. © 2012 IEEE.