Browsing by Subject "BODIPY dyes"

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    ItemOpen Access
    Development of a water-soluble 3-formylBODIPY dye for fluorogenic sensing and cell imaging of sulfur dioxide derivatives
    (Elsevier, 2019) Işık, M.; Turan, İlke Şimşek; Dartar, S.
    A new water-soluble, highly fluorogenic 3-formylBODIPY dye that enables the sensing of SO2derivativesin aqueous buffers and cancer cells is reported. The quaternary ammonium group appended through themeso-position of the BODIPY dye ensures water solubility. The probe exhibits high specificity for cytosolic(bi)sulfites and fluoresces brightly in human lung adenocarcinoma cells (A549).
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    ItemOpen Access
    Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
    (Wiley-VCH Verlag, 2014) Turan, I. S.; Cakmak, F. P.; Yildirim, D. C.; Cetin Atalay, R.; Akkaya, E. U.
    Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.