Browsing by Author "Toksoz, S."
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Item Open Access Electrostatic effects on nanofiber formation of self-assembling peptide amphiphiles(Elsevier, 2011) Toksoz, S.; Mammadov R.; Tekinay, A. B.; Güler, Mustafa O.Self-assembling peptide amphiphile molecules have been of interest to various tissue engineering studies. These molecules self-assemble into nanofibers which organize into three-dimensional networks to form hydrocolloid systems mimicking the extracellular matrix. The formation of nanofibers is affected by the electrostatic interactions among the peptides. In this work, we studied the effect of charged groups on the peptides on nanofiber formation. The self-assembly process was studied by pH and zeta potential measurements, FT-IR, circular dichroism, rheology, atomic force microscopy, scanning electron microscopy and transmission electron microscopy. The aggregation of the peptides was triggered upon neutralization of the charged residues by pH change or addition of electrolyte or biomacromolecules. Understanding the controlled formation of the hydrocolloid gels composed of peptide amphiphile nanofibers can lead us to develop in situ gel forming bioactive collagen mimetic nanofibers for various tissue engineering studies including bioactive surface coatings. © 2010 Elsevier Inc.Item Open Access Self-assembled one-dimensional soft nanostructures(Royal Society of Chemistry, 2010) Toksoz, S.; Acar, H.; Güler, Mustafa O.The self-assembly process is a bottom-up approach and is the spontaneous aggregation of many different subunits into well-defined functional structures with varying properties. Self-assembly is an attractive method to develop one-dimensional nanostructures and is controlled by many factors including temperature, pH and electrolyte addition. Novel self-assembled one-dimensional nanostructures are finding applications in regenerative medicine and electronics as well as in fabrication of nanoscale electronic, mechanic, magnetic, optical, and combinatorial devices. Their utility comes from their high ratio of surface area to volume, and their quantum-confinement effects. This paper reviews one-dimensional self-assembled organic nanostructures classified according to the noncovalent forces acting on their formation.Item Open Access Self-assembled peptidic nanostructures(Elsevier, 2009) Toksoz, S.; Güler, Mustafa O.Understanding the mechanisms of molecular self-assembly processes in natural materials is an important step to developing new functional materials with useful properties. Recently, various self-assembled materials have gained attention because of their interesting properties in nanoscale. Nanostructures composed of peptides are especially of interest in materials development because of their many advantageous properties such as biodegradability, biocompatibility and customizable bioactivity. Self-assembled peptidic nanostructures have been studied by many research groups and found use as three-dimensional cell scaffolds for bone regeneration, dental implants, neural tissue engineering, biosensors for detection of viruses and other pathogens, antibacterial agents and in drug, protein and gene delivery.