Browsing by Author "Ahsen, V."

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    Design of a Gd-DOTA-phthalocyanine conjugate combining MRI contrast imaging and photosensitization properties as a potential molecular theranostic
    (Wiley-Blackwell Publishing, Inc., 2014) Tekdaş, D. A.; Garifullin, Ruslan; Şentürk, Berna; Zorlu, Y.; Gundogdu, Umut; Atalar, Ergin; Tekinay, Ayse B.; Chernonosov, A. A.; Yerli, Y.; Dumoulin, F.; Güler, Mustafa O.; Ahsen, V.; Gürek, A. G.
    The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.
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    Encapsulation of a zinc phthalocyanine derivative in self-assembled peptide nanofibers
    (The Royal Society of Chemistry, 2012) Garifullin, R.; Erkal, T. S.; Tekin, S.; Ortaç, B.; Gürek, A. G.; Ahsen, V.; Yaglioglu, H. G.; Elmali, A.; Güler, Mustafa O.
    In this article, we demonstrate encapsulation of octakis(hexylthio) zinc phthalocyanine molecules by non-covalent supramolecular organization within self-assembled peptide nanofibers. Peptide nanofibers containing octakis(hexylthio) zinc phthalocyanine molecules were obtained via a straight-forward one-step self-assembly process under aqueous conditions. Nanofiber formation results in the encapsulation and organization of the phthalocyanine molecules, promoting ultrafast intermolecular energy transfer. The morphological, mechanical, spectroscopic and non-linear optical properties of phthalocyanine containing peptide nanofibers were characterized by TEM, SEM, oscillatory rheology, UV-Vis, fluorescence, ultrafast pump-probe and circular dichroism spectroscopy techniques. The ultrafast pump-probe experiments of octakis(hexylthio) zinc phthalocyanine molecules indicated pH controlled non-linear optical characteristics of the encapsulated molecules within self-assembled peptide nanofibers. This method can provide a versatile approach for bottom-up fabrication of supramolecular organic electronic devices. © 2012 The Royal Society of Chemistry.