Scholarly Publications - UNAM

Permanent URI for this collectionhttps://hdl.handle.net/11693/117076

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Browsing Scholarly Publications - UNAM by Author "Abd El-Aty, A. M."

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    Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
    (BioMed Central, 2024-06-24) Zhang, Xian-Bin; Fan, Yi-Bao; Jing, Rui; Getu, Mikiyas Amare; Chen, Wan-Ying; Zhang, Wei; Dong, Hong-Xia; Dakal, Tikam Chand; Hayat, Akhtar; Cai, Hua-Jun; Ashrafizadeh, Milad; Abd El-Aty, A. M.; Hacimuftuoglu, Ahmet; Liu, Peng; Li, Tian-Feng; Sethi, Gautam; Ahn, Kwang Seok; Ertas, Yavuz Nuri; Chen, Min-Jiang; Ji, Jian-Song; Ma, Li; Gong, Peng
    Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.