Modeling cellular processes with PATİKA

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buir.advisorÇetin-Atalay, Rengül
dc.contributor.authorDemir, Emek
dc.date.accessioned2016-01-08T18:02:11Z
dc.date.available2016-01-08T18:02:11Z
dc.date.issued2001
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionAnkara : The Department of Molecular Biology and Genetics and the Institute of Engineering and Science of Bilkent University, 2001.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2001.en_US
dc.descriptionIncludes bibliographical references leaves 49-51en_US
dc.description.abstractAvailability of the sequences of entire genomes shifts the scientific curiosity toward the identification of function of the genomes in large scale as in genome studies. In the near future data produced about cellular processes at molecular level will accumulate with an accelerating rate as a result of proteomics studies. In this regard, it is essential to develop tools for storing, integrating, accessing, and analyzing this data effectively. We define an ontology for a comprehensive representation of cellular events. The model presented here enables integration of fragmented or incomplete pathway information and supports manipulation and incorporations of the stored data, as well as multiple levels of abstraction. Based on this model, we present an integrated environment named PATIKA (Pathway Analysis Tool for Integration and Knowledge Acquisition). PATIKA is composed of a server-side, scalable, object-oriented database and client-side editors to provide an integrated, multi-user environment for visualizing and manipulating network of cellular events. This tool features automated pathway layout, functional computation support, advanced querying and a user-friendly graphical interface. We expect that PATIKA will be a valuable tool for rapid knowledge acquisition; micro array generated large-scale data interpretation; disease gene identification and drug developmenten_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityDemir, Emeken_US
dc.format.extent51 leaves, illustrationsen_US
dc.identifier.urihttp://hdl.handle.net/11693/14564
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbioinformaticsen_US
dc.subjectontologyen_US
dc.subjectautomated layouten_US
dc.subjectobject oriented databaseen_US
dc.subjectcellular pathwaysen_US
dc.subject.lccQH323.5 .D46 2001en_US
dc.subject.lcshBioinformatics.en_US
dc.subject.lcshObject-oriented data bases.en_US
dc.subject.lcshOntology.en_US
dc.titleModeling cellular processes with PATİKAen_US
dc.typeThesisen_US
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