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      • Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.
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      • Theses - Graduate Program in Materials Science and Nanotechnology
      • Graduate Program in Materials Science and Nanotechnology - Ph.D. / Sc.D.
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      Molecular analysis of enginereed nanomaterials in biomedical and regenerative medicine applications

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      Embargo Lift Date: 2019-11-29
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      Author(s)
      Gündüz, Nuray
      Advisor
      Elbüken, Çağlar
      Date
      2019-04
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Molecular mechanisms are inspiration source for effective nanomaterial synthesis through minimalist bottom-up approaches. Mimicking functional biophysicochemical properties of biomacromolecules can give new insights for design and synthesis of nanomaterials used in biomedical and regenerative medicine applications. In this thesis, rationally-designed nanomaterials and their biomedical applications as oral ketone delivery and biomineralization and long-term potential toxicities were investigated. In the first chapter, basic concepts of nanomaterial design, synthesis, characterization, and nano-bio interface were explained. In the second chapter, a novel long-term nanoparticle accumulation model was developed to understand active regulation of nanoparticle uptake, nanoparticle accumulation behavior and the impact of long-term exposure on cellular machineries (e.g. ER stress). In the third chapter, the role of ketone body betahydroxybutryrate (βOHB) generated by a metabolic enzyme, hydroxymethylglutaryl CoA synthase 2 (HMGCS2), on intestinal stem cell maintenance and regeneration after radiation injury was investigated. Consequences of βOHB depletion in intestine were rectified by oral delivery of PLGA-encapsulated and oligomer forms of βOHB. The last chapter, acidic epitopes of enamel proteins (e.g. amelogenin) were integrated into self-assembling peptides to remineralize eroded enamel. Overall these studies show potential of natureinspired engineered nanomaterials in vast range of biomedical and regenerative medicine applications.
      Keywords
      Nanoparticle; toxicity
      Cell-nanomaterial interactions
      Gold nanoparticles; nanoparticle accumulation
      Organoid
      HMGCS2
      Beta hydroxybutyrate
      Small intestine
      Oral ketone delivery
      Mineralization
      Enamel
      Self-assembling peptide
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      http://hdl.handle.net/11693/51971
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