Molecular analysis of enginereed nanomaterials in biomedical and regenerative medicine applications

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buir.advisorElbüken, Çağlar
dc.contributor.authorGündüz, Nuray
dc.date.accessioned2019-05-31T06:46:31Z
dc.date.available2019-05-31T06:46:31Z
dc.date.copyright2019-04
dc.date.issued2019-04
dc.date.submitted2019-05-29
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2019.en_US
dc.descriptionIncludes bibliographical references (leaves 110-118).en_US
dc.description.abstractMolecular mechanisms are inspiration source for effective nanomaterial synthesis through minimalist bottom-up approaches. Mimicking functional biophysicochemical properties of biomacromolecules can give new insights for design and synthesis of nanomaterials used in biomedical and regenerative medicine applications. In this thesis, rationally-designed nanomaterials and their biomedical applications as oral ketone delivery and biomineralization and long-term potential toxicities were investigated. In the first chapter, basic concepts of nanomaterial design, synthesis, characterization, and nano-bio interface were explained. In the second chapter, a novel long-term nanoparticle accumulation model was developed to understand active regulation of nanoparticle uptake, nanoparticle accumulation behavior and the impact of long-term exposure on cellular machineries (e.g. ER stress). In the third chapter, the role of ketone body betahydroxybutryrate (βOHB) generated by a metabolic enzyme, hydroxymethylglutaryl CoA synthase 2 (HMGCS2), on intestinal stem cell maintenance and regeneration after radiation injury was investigated. Consequences of βOHB depletion in intestine were rectified by oral delivery of PLGA-encapsulated and oligomer forms of βOHB. The last chapter, acidic epitopes of enamel proteins (e.g. amelogenin) were integrated into self-assembling peptides to remineralize eroded enamel. Overall these studies show potential of natureinspired engineered nanomaterials in vast range of biomedical and regenerative medicine applications.en_US
dc.description.degreePh.D.en_US
dc.description.statementofresponsibilityby Nuray Gündüzen_US
dc.embargo.release2019-11-29
dc.format.extentxx, 121 leaves : illustrations (some color), charts (some color) ; 30 cm.en_US
dc.identifier.itemidB156418
dc.identifier.urihttp://hdl.handle.net/11693/51971
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanoparticle; toxicityen_US
dc.subjectCell-nanomaterial interactionsen_US
dc.subjectGold nanoparticles; nanoparticle accumulationen_US
dc.subjectOrganoiden_US
dc.subjectHMGCS2en_US
dc.subjectBeta hydroxybutyrateen_US
dc.subjectSmall intestineen_US
dc.subjectOral ketone deliveryen_US
dc.subjectMineralizationen_US
dc.subjectEnamelen_US
dc.subjectSelf-assembling peptideen_US
dc.titleMolecular analysis of enginereed nanomaterials in biomedical and regenerative medicine applicationsen_US
dc.title.alternativeBiyomedikal ve yenileyici tıp uygulamalarında kullanılan nanomalzemelerin moleküler seviyede incelenmesien_US
dc.typeThesisen_US
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