Model-Driven Software Development (MDSD) aims to support the development and evolution of software intensive systems using the basic concepts of model, metamodel, and model transformation. In parallel with the ongoing academic research, MDSD is more and more applied in industrial practices. Like conventional non-MDSD practices, MDSD systems are also subject to changing requirements and have to cope with evolution. In this chapter, the authors provide a scenario-based approach for documenting and analyzing the impact of changes that apply to model-driven development systems. To model the composition and evolution of an MDSD system, they developed the so-called Model-Driven Software Evolution Language (MoDSEL) which is based on a megamodel for MDSD. MoDSEL includes explicit language abstractions to specify both the model elements of an MDSD system and the evolution scenarios that might apply to model elements. Based on MoDSEL specifications, an impact analysis is performed to assess the impact of evolution scenarios and the sensitivity of model elements. A case study is provided to show different kind of evolution scenarios and the required adaptations to model elements. © 2014, IGI Global.