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      Building and improving reference genome assemblies

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      Author(s)
      Steinberg, K. M.
      Schneider, V. A.
      Alkan, Can
      Montague, M. J.
      Warren, W. C.
      Church, D. M.
      Wilson, R. K.
      Date
      2017-01
      Source Title
      Proceedings of the IEEE
      Publisher
      IEEE
      Pages
      422 - 435
      Language
      English
      Type
      Conference Paper
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      Abstract
      A genome sequence assembly provides the foundation for studies of genotypic and phenotypic variation, genome structure, and evolution of the target organism. In the past four decades, there has been a surge of new sequencing technologies, and with these developments, computational scientists have developed new algorithms to improve genome assembly. Here we discuss the relationship between sequencing technology improvements and assembly algorithm development and how these are applied to extend and improve human and nonhuman genome assemblies. © 1963-2012 IEEE.
      Keywords
      Bioinformatics
      DNA
      Genetics
      Genomics
      Permalink
      http://hdl.handle.net/11693/37616
      Published Version (Please cite this version)
      http://dx.doi.org/10.1109/JPROC.2016.2645402
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      • Department of Computer Engineering 1561
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