Building and improving reference genome assemblies

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dc.citation.epage435en_US
dc.citation.spage422en_US
dc.contributor.authorSteinberg, K. M.en_US
dc.contributor.authorSchneider, V. A.en_US
dc.contributor.authorAlkan, Canen_US
dc.contributor.authorMontague, M. J.en_US
dc.contributor.authorWarren, W. C.en_US
dc.contributor.authorChurch, D. M.en_US
dc.contributor.authorWilson, R. K.en_US
dc.date.accessioned2018-04-12T11:45:48Z
dc.date.available2018-04-12T11:45:48Z
dc.date.issued2017-01en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.descriptionDate of Publication: 27 January 2017
dc.descriptionConference name: Proceedings of the IEEE
dc.description.abstractA genome sequence assembly provides the foundation for studies of genotypic and phenotypic variation, genome structure, and evolution of the target organism. In the past four decades, there has been a surge of new sequencing technologies, and with these developments, computational scientists have developed new algorithms to improve genome assembly. Here we discuss the relationship between sequencing technology improvements and assembly algorithm development and how these are applied to extend and improve human and nonhuman genome assemblies. © 1963-2012 IEEE.en_US
dc.identifier.doi10.1109/JPROC.2016.2645402en_US
dc.identifier.urihttp://hdl.handle.net/11693/37616
dc.language.isoEnglishen_US
dc.publisherIEEEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1109/JPROC.2016.2645402en_US
dc.source.titleProceedings of the IEEEen_US
dc.subjectBioinformaticsen_US
dc.subjectDNAen_US
dc.subjectGeneticsen_US
dc.subjectGenomicsen_US
dc.titleBuilding and improving reference genome assembliesen_US
dc.typeConference Paperen_US
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Building and Improving Reference Genome Assemblies This paper reviews the problems and algorithms of assembling a complete genome from millions of short DNA sequencing reads.pdf
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