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      Like-Charge Attraction And Opposite-Charge Decomplexation Between Polymers and DNA Molecules

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      Author(s)
      Buyukdagli, S.
      Date
      2017
      Source Title
      Physical Review E
      Print ISSN
      2470-0045
      Publisher
      American Physical Society
      Volume
      95
      Issue
      2
      Pages
      1 - 14
      Language
      English
      Type
      Article
      Item Usage Stats
      185
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      Abstract
      We scrutinize the effect of polyvalent ions on polymer-DNA interactions. We extend a recently developed test-charge theory [S. Buyukdagli, Phys. Rev. E 94, 042502 (2016)1539-375510.1103/PhysRevE.94.042502] to the case of a stiff polymer interacting with a DNA molecule in an electrolyte mixture. The theory accounts for one-loop level electrostatic correlation effects such as the ionic cloud deformation around the strongly charged DNA molecule as well as image-charge forces induced by the low DNA permittivity. Our model can reproduce and explain various characteristics of the experimental phase diagrams for polymer solutions. First, the addition of polyvalent cations to the electrolyte solution results in the attraction of the negatively charged polymer by the DNA molecule. The glue of the like-charge attraction is the enhanced shielding of the polymer charges by the dense counterion layer at the DNA surface. Second, through the shielding of the DNA-induced electrostatic potential, mono- and polyvalent cations of large concentration both suppress the like-charge attraction. Within the same formalism, we also predict a new opposite-charge repulsion effect between the DNA molecule and a positively charged polymer. In the presence of polyvalent anions such as sulfate or phosphate, their repulsion by the DNA charges leads to the charge screening deficiency of the region around the DNA molecule. This translates into a repulsive force that results in the decomplexation of the polymer from DNA. This opposite-charge repulsion phenomenon can be verified by current experiments and the underlying mechanism can be beneficial to gene therapeutic applications where the control over polymer-DNA interactions is the key factor.
      Keywords
      Electrolytes
      Electrostatics
      Functional polymers
      Gene therapy
      Ions
      Molecules
      Positive ions
      Shielding
      Electrolyte mixtures
      Electrolyte solutions
      Electrostatic correlation
      Electrostatic potentials
      Image charge force
      Negatively charged
      Polyvalent cations
      Therapeutic Application
      DNA
      Permalink
      http://hdl.handle.net/11693/37131
      Published Version (Please cite this version)
      http://dx.doi.org/10.1103/PhysRevE.95.022502
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