Like-Charge Attraction And Opposite-Charge Decomplexation Between Polymers and DNA Molecules

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dc.citation.epage14en_US
dc.citation.issueNumber2en_US
dc.citation.spage1en_US
dc.citation.volumeNumber95en_US
dc.contributor.authorBuyukdagli, S.en_US
dc.date.accessioned2018-04-12T11:03:35Z
dc.date.available2018-04-12T11:03:35Z
dc.date.issued2017en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractWe scrutinize the effect of polyvalent ions on polymer-DNA interactions. We extend a recently developed test-charge theory [S. Buyukdagli, Phys. Rev. E 94, 042502 (2016)1539-375510.1103/PhysRevE.94.042502] to the case of a stiff polymer interacting with a DNA molecule in an electrolyte mixture. The theory accounts for one-loop level electrostatic correlation effects such as the ionic cloud deformation around the strongly charged DNA molecule as well as image-charge forces induced by the low DNA permittivity. Our model can reproduce and explain various characteristics of the experimental phase diagrams for polymer solutions. First, the addition of polyvalent cations to the electrolyte solution results in the attraction of the negatively charged polymer by the DNA molecule. The glue of the like-charge attraction is the enhanced shielding of the polymer charges by the dense counterion layer at the DNA surface. Second, through the shielding of the DNA-induced electrostatic potential, mono- and polyvalent cations of large concentration both suppress the like-charge attraction. Within the same formalism, we also predict a new opposite-charge repulsion effect between the DNA molecule and a positively charged polymer. In the presence of polyvalent anions such as sulfate or phosphate, their repulsion by the DNA charges leads to the charge screening deficiency of the region around the DNA molecule. This translates into a repulsive force that results in the decomplexation of the polymer from DNA. This opposite-charge repulsion phenomenon can be verified by current experiments and the underlying mechanism can be beneficial to gene therapeutic applications where the control over polymer-DNA interactions is the key factor.en_US
dc.identifier.doi10.1103/PhysRevE.95.022502en_US
dc.identifier.issn2470-0045
dc.identifier.urihttp://hdl.handle.net/11693/37131
dc.language.isoEnglishen_US
dc.publisherAmerican Physical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1103/PhysRevE.95.022502en_US
dc.source.titlePhysical Review Een_US
dc.subjectElectrolytesen_US
dc.subjectElectrostaticsen_US
dc.subjectFunctional polymersen_US
dc.subjectGene therapyen_US
dc.subjectIonsen_US
dc.subjectMoleculesen_US
dc.subjectPositive ionsen_US
dc.subjectShieldingen_US
dc.subjectElectrolyte mixturesen_US
dc.subjectElectrolyte solutionsen_US
dc.subjectElectrostatic correlationen_US
dc.subjectElectrostatic potentialsen_US
dc.subjectImage charge forceen_US
dc.subjectNegatively chargeden_US
dc.subjectPolyvalent cationsen_US
dc.subjectTherapeutic Applicationen_US
dc.subjectDNAen_US
dc.titleLike-Charge Attraction And Opposite-Charge Decomplexation Between Polymers and DNA Moleculesen_US
dc.typeArticleen_US
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