• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Institute of Materials Science and Nanotechnology (UNAM)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers

      Thumbnail
      View / Download
      1.4 Mb
      Author(s)
      Aytaç, Zeynep
      Uyar, Tamer
      Date
      2016-06
      Source Title
      European Polymer Journal
      Print ISSN
      0014-3057
      Publisher
      Elsevier
      Volume
      79
      Pages
      140 - 149
      Language
      English
      Type
      Article
      Item Usage Stats
      186
      views
      212
      downloads
      Abstract
      Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known antioxidant molecule, α-tocopherol (α-TC) (vitamin E) was chosen as an active agent for inclusion complexation with β-cyclodextrin. Polycaprolactone (PCL) nanofibers encapsulating α-tocopherol/β-cyclodextrin inclusion complex (α-TC/β-CD-IC) which has high antioxidant activity and photostability was produced via electrospinning (PCL/α-TC/β-CD-IC-NF). The formation of α-TC/β-CD-IC was confirmed by XRD. Phase solubility studies showed An-type complex formation between α-TC and β-CD. SEM revealed that bead-free nanofibers were successfully produced from PCL/α-TC/β-CD-IC system. PCL nanofibers encapsulating α-TC without CD-IC was also produced for comparison (PCL/α-TC-NF). Antioxidant test results showed that PCL/α-TC/β-CD-IC-NF had higher antioxidant activity as compared to PCL/α-TC-NF in methanol:water (1:1) system due to the stabilization and solubility increment of α-TC in the cavity of β-CD. PCL/α-TC/β-CD-IC-NF was more stable against UV-light when compared to PCL/α-TC-NF due to the presence of inclusion complexation. In brief, PCL/α-TC/β-CD-IC-NF with the advantages of having nanofibrous structure and encapsulating CD-ICs, may serve as a novel route for administration of α-TC due to its higher antioxidant activity and better UV-light stability.
      Keywords
      Antioxidant activity
      Nanofiber
      Photostability
      Polycaprolactone
      α-Tocopherol
      β-Cyclodextrin
      Permalink
      http://hdl.handle.net/11693/36838
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.eurpolymj.2016.04.029
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      LoginRegister

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy