Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers

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buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage149en_US
dc.citation.spage140en_US
dc.citation.volumeNumber79en_US
dc.contributor.authorAytaç, Zeynepen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2018-04-12T10:55:06Z
dc.date.available2018-04-12T10:55:06Z
dc.date.issued2016-06en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractCyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known antioxidant molecule, α-tocopherol (α-TC) (vitamin E) was chosen as an active agent for inclusion complexation with β-cyclodextrin. Polycaprolactone (PCL) nanofibers encapsulating α-tocopherol/β-cyclodextrin inclusion complex (α-TC/β-CD-IC) which has high antioxidant activity and photostability was produced via electrospinning (PCL/α-TC/β-CD-IC-NF). The formation of α-TC/β-CD-IC was confirmed by XRD. Phase solubility studies showed An-type complex formation between α-TC and β-CD. SEM revealed that bead-free nanofibers were successfully produced from PCL/α-TC/β-CD-IC system. PCL nanofibers encapsulating α-TC without CD-IC was also produced for comparison (PCL/α-TC-NF). Antioxidant test results showed that PCL/α-TC/β-CD-IC-NF had higher antioxidant activity as compared to PCL/α-TC-NF in methanol:water (1:1) system due to the stabilization and solubility increment of α-TC in the cavity of β-CD. PCL/α-TC/β-CD-IC-NF was more stable against UV-light when compared to PCL/α-TC-NF due to the presence of inclusion complexation. In brief, PCL/α-TC/β-CD-IC-NF with the advantages of having nanofibrous structure and encapsulating CD-ICs, may serve as a novel route for administration of α-TC due to its higher antioxidant activity and better UV-light stability.en_US
dc.identifier.doi10.1016/j.eurpolymj.2016.04.029en_US
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/11693/36838
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.eurpolymj.2016.04.029en_US
dc.source.titleEuropean Polymer Journalen_US
dc.subjectAntioxidant activityen_US
dc.subjectNanofiberen_US
dc.subjectPhotostabilityen_US
dc.subjectPolycaprolactoneen_US
dc.subjectα-Tocopherolen_US
dc.subjectβ-Cyclodextrinen_US
dc.titleAntioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibersen_US
dc.typeArticleen_US
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