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      One-pot, benzylic amination reactions of azine N-oxides

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      Embargo Lift Date: 2018-07-04
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      Author
      Liman, Menekşe
      Advisor
      Türkmen, Yunus Emre
      Date
      2017-07
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Nitrogen-containing aromatic heterocycles, found in many biologically active natural products and pharmaceutical drugs, constitute a highly important class of compounds in organic chemistry. In this context, areas such as the discoveries of new synthetic methods for both the synthesis and derivatization of nitrogen-containing heterocyclic compounds as well as for the introduction of nitrogen to a compound attract significant attention in the areas of organic and pharmaceutical chemistry. In this study, we have developed a new one-pot synthetic method for the benzylic amination of azine-N-oxides containing a methyl group at the 2-position. Following the optimization studies, the substrate scope of the developed reaction has been investigated in detail. The reaction tolerates quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partner as well as a broad range of nucleophilic primary, secondary and aromatic amines.
      Keywords
      Heterocyclic compounds
      Azine N-Oxides
      Benzylic amination
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      http://hdl.handle.net/11693/33382
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      • Dept. of Chemistry - Master's degree 129
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