One-pot, benzylic amination reactions of azine N-oxides
| buir.advisor | Türkmen, Yunus Emre | |
| dc.contributor.author | Liman, Menekşe | |
| dc.date.accessioned | 2017-07-11T13:37:07Z | |
| dc.date.available | 2017-07-11T13:37:07Z | |
| dc.date.copyright | 2017-06 | |
| dc.date.issued | 2017-06 | |
| dc.date.submitted | 2017-07-04 | |
| dc.department | Department of Chemistry | en_US |
| dc.description | Cataloged from PDF version of article. | en_US |
| dc.description | Thesis (M.S.): Bilkent University, Department of Chemistry, İhsan Doğramacı Bilkent University, 2017. | en_US |
| dc.description | Includes bibliographical references (leaves 68-78). | en_US |
| dc.description.abstract | Nitrogen-containing aromatic heterocycles, found in many biologically active natural products and pharmaceutical drugs, constitute a highly important class of compounds in organic chemistry. In this context, areas such as the discoveries of new synthetic methods for both the synthesis and derivatization of nitrogen-containing heterocyclic compounds as well as for the introduction of nitrogen to a compound attract significant attention in the areas of organic and pharmaceutical chemistry. In this study, we have developed a new one-pot synthetic method for the benzylic amination of azine-N-oxides containing a methyl group at the 2-position. Following the optimization studies, the substrate scope of the developed reaction has been investigated in detail. The reaction tolerates quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partner as well as a broad range of nucleophilic primary, secondary and aromatic amines. | en_US |
| dc.description.degree | M.S. | en_US |
| dc.description.statementofresponsibility | by Menekşe Liman. | en_US |
| dc.embargo.release | 2018-07-04 | |
| dc.format.extent | xvii, 117 leaves : illustrations, charts (some color) ; 29 cm. | en_US |
| dc.identifier.itemid | B155881 | |
| dc.identifier.uri | http://hdl.handle.net/11693/33382 | |
| dc.language.iso | English | en_US |
| dc.publisher | Bilkent University | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Heterocyclic compounds | en_US |
| dc.subject | Azine N-Oxides | en_US |
| dc.subject | Benzylic amination | en_US |
| dc.title | One-pot, benzylic amination reactions of azine N-oxides | en_US |
| dc.title.alternative | Azin N-oksit bileşiklerinin benzilik aminasyonu | en_US |
| dc.type | Thesis | en_US |