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      Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells

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      Author(s)
      Khalily, M. A.
      Gulseren, G.
      Tekinay, A. B.
      Güler, Mustafa O.
      Date
      2015
      Source Title
      Bioconjugate Chemistry
      Print ISSN
      1043-1802
      Publisher
      American Chemical Society
      Volume
      26
      Issue
      12
      Pages
      2371 - 2375
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.
      Keywords
      Alkyne
      Amphophile
      Azide
      Copper ion
      Nanofiber
      Article
      Cell function
      Cell labeling
      Chemical reaction
      Click chemistry
      Controlled study
      Cycloaddition
      Cytotoxicity
      Nanocatalyst
      Supramolecular chemistry
      Permalink
      http://hdl.handle.net/11693/25035
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/acs.bioconjchem.5b00443
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2258
      • Nanotechnology Research Center (NANOTAM) 1179
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