Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells
Date
2015Source Title
Bioconjugate Chemistry
Print ISSN
1043-1802
Publisher
American Chemical Society
Volume
26
Issue
12
Pages
2371 - 2375
Language
English
Type
ArticleItem Usage Stats
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Abstract
Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.
Keywords
AlkyneAmphophile
Azide
Copper ion
Nanofiber
Article
Cell function
Cell labeling
Chemical reaction
Click chemistry
Controlled study
Cycloaddition
Cytotoxicity
Nanocatalyst
Supramolecular chemistry