Biocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cells

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage2375en_US
dc.citation.issueNumber12en_US
dc.citation.spage2371en_US
dc.citation.volumeNumber26en_US
dc.contributor.authorKhalily, M. A.en_US
dc.contributor.authorGulseren, G.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2016-02-08T10:38:06Z
dc.date.available2016-02-08T10:38:06Z
dc.date.issued2015en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractUnderstanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells.en_US
dc.identifier.doi10.1021/acs.bioconjchem.5b00443en_US
dc.identifier.issn1043-1802
dc.identifier.urihttp://hdl.handle.net/11693/25035
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00443en_US
dc.source.titleBioconjugate Chemistryen_US
dc.subjectAlkyneen_US
dc.subjectAmphophileen_US
dc.subjectAzideen_US
dc.subjectCopper ionen_US
dc.subjectNanofiberen_US
dc.subjectArticleen_US
dc.subjectCell functionen_US
dc.subjectCell labelingen_US
dc.subjectChemical reactionen_US
dc.subjectClick chemistryen_US
dc.subjectControlled studyen_US
dc.subjectCycloadditionen_US
dc.subjectCytotoxicityen_US
dc.subjectNanocatalysten_US
dc.subjectSupramolecular chemistryen_US
dc.titleBiocompatible supramolecular catalytic one-dimensional nanofibers for efficient labeling of live cellsen_US
dc.typeArticleen_US
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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)