pH-responsive near-infrared emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery

Date
2014
Authors
Pennakalathil, J.
Özgün, A.
Durmaz, I.
Cetin Atalay, R.
Tuncel, D.
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Journal of Polymer Science, Part A: Polymer Chemistry
Print ISSN
0887-624X
Electronic ISSN
1099-0518
Publisher
John Wiley and Sons Inc.
Volume
53
Issue
1
Pages
114 - 122
Language
English
Journal Title
Journal ISSN
Volume Title
Series
Abstract

In this article, pH-responsive near-infrared emitting conjugated polymer nanoparticles (CPNs) are prepared, characterized, and their stabilities are investigated under various conditions. These nanoparticles have capacity to be loaded with water insoluble, anticancer drug, camptothecin (CPT), with around 10% drug loading efficiency. The in vitro release studies demonstrate that the release of CPTs from CPNs is pHdependent such that significantly faster drug release at mildly acidic pH of 5.0 compared with physiological pH 7.4 is observed. Time and dose-dependent in vitro cytotoxicity tests of blank and CPT-loaded nanoparticles are performed by realtime cell electronic sensing (RT-CES) assay with hepatocellular carcinoma cells (Huh7). The results indicate that CPNs can be effectively utilized as vehicles for pH-triggered release of anticancer drugs.

Course
Other identifiers
Book Title
Citation
Published Version (Please cite this version)