pH-responsive near-infrared emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery

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dc.citation.epage122en_US
dc.citation.issueNumber1en_US
dc.citation.spage114en_US
dc.citation.volumeNumber53en_US
dc.contributor.authorPennakalathil, J.en_US
dc.contributor.authorÖzgün, A.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorTuncel, D.en_US
dc.date.accessioned2016-02-08T10:14:43Z
dc.date.available2016-02-08T10:14:43Z
dc.date.issued2014en_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractIn this article, pH-responsive near-infrared emitting conjugated polymer nanoparticles (CPNs) are prepared, characterized, and their stabilities are investigated under various conditions. These nanoparticles have capacity to be loaded with water insoluble, anticancer drug, camptothecin (CPT), with around 10% drug loading efficiency. The in vitro release studies demonstrate that the release of CPTs from CPNs is pHdependent such that significantly faster drug release at mildly acidic pH of 5.0 compared with physiological pH 7.4 is observed. Time and dose-dependent in vitro cytotoxicity tests of blank and CPT-loaded nanoparticles are performed by realtime cell electronic sensing (RT-CES) assay with hepatocellular carcinoma cells (Huh7). The results indicate that CPNs can be effectively utilized as vehicles for pH-triggered release of anticancer drugs.en_US
dc.identifier.doi10.1002/pola.27458en_US
dc.identifier.eissn1099-0518
dc.identifier.issn0887-624X
dc.identifier.urihttp://hdl.handle.net/11693/23492
dc.language.isoEnglishen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/pola.27458en_US
dc.source.titleJournal of Polymer Science, Part A: Polymer Chemistryen_US
dc.subjectCellular imagingen_US
dc.subjectConjugated polymersen_US
dc.subjectDrug delivery systemsen_US
dc.subjectLuminescenceen_US
dc.subjectNanoparticlesen_US
dc.subjectNear IR emissionen_US
dc.subjectpH-responsiveen_US
dc.titlepH-responsive near-infrared emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug deliveryen_US
dc.typeArticleen_US
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Department of Chemistry
Department of Molecular Biology and Genetics
Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)