Neutral particle mass spectrometry with nanomechanical systems
Nature Publishing Group
Item Usage Stats
MetadataShow full item record
Current approaches to mass spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. Here, using a setup comprising both conventional time-of-flight MS (TOF-MS) and nano-electromechanical systems-based MS (NEMS-MS) in situ, we show directly that NEMS-MS analysis is insensitive to charge state: the spectrum consists of a single peak whatever the speciesa' charge state, making it significantly clearer than existing MS analysis. In subsequent tests, all the charged particles are electrostatically removed from the beam, and unlike TOF-MS, NEMS-MS can still measure masses. This demonstrates the possibility to measure mass spectra for neutral particles. Thus, it is possible to envisage MS-based studies of analytes that are incompatible with current ionization techniques and the way is now open for the development of cutting-edge system architectures with unique analytical capability. © 2015 Macmillan Publishers Limited.
in situ test
neutral particle mass spectrometry
time of flight mass spectrometry
Published Version (Please cite this version)http://dx.doi.org/10.1038/ncomms7482
Showing items related by title, author, creator and subject.
Cyclodextrin functionalized poly(methyl methacrylate) (PMMA) electrospun nanofibers for organic vapors waste treatment Uyar T.; Havelund, R.; Nur, Y.; Balan, A.; Hacaloglu, J.; Toppare, L.; Besenbacher, F.; Kingshott, P. (Elsevier BV, 2010)Poly(methyl methacrylate) (PMMA) nanofibers containing the inclusion complex forming betacyclodextrin (_-CD) were successfully produced by means of electrospinning in order to develop functional nanofibrous webs for ...
The formation and characterization of cyclodextrin functionalized polystyrene nanofibers produced by electrospinning Uyar T.; Havelund, R.; Hacaloglu J.; Zhou X.; Besenbacher F.; Kingshott P. (2009)Polystyrene (PS) nanofibers containing the inclusion complex forming beta-cyclodextrin (β-CD) were successfully produced by electrospinning aimed at developing functional fibrous nanowebs. By optimization of the electrospinning ...
Parametric power spectral density analysis of noise from instrumentation in MALDI TOF mass spectrometry Shin H.; Mutlu, M.; Koomen J.M.; Markey, M.K. (2007)Noise in mass spectrometry can interfere with identification of the biochemical substances in the sample. For example, the electric motors and circuits inside the mass spectrometer or in nearby equipment generate random ...