Multi-domain short peptide molecules for in situ synthesis and biofunctionalization of gold nanoparticles for integrin-targeted cell uptake
Gulsuner, H. U.
Guler, M. O.
Tekinay, A. B.
ACS Applied Materials and Interfaces
American Chemical Society
10677 - 10683
Item Usage Stats
MetadataShow full item record
We describe design and synthesis model of multidomain (modular) peptides (MDPs), which direct a reaction cascade coupling the synthesis and surface functionalization of gold nanoparticles (AuNPs) in a single step. The synthesis is achieved via simple mixing of the aqueous solutions of auric acid and MDPs at room temperature without the addition of any surfactants or toxic intermediate reagents. This method allows facile control over the nanoparticle size between ∼2–15 nm, which opens a practical window for biomedical applications. In contrast to the conventional citrate-mediated methods, peptide-mediated synthesis and stabilization provide increased colloidal stability to AuNPs. As a proof of this concept, we demonstrate active targeting of human breast adenocarcinoma cell line (MCF7) using the one-step-prepared engineered AuNPs. Overall, we propose a single-step, chemically greener, biologically safer method for the synthesis and surface functionalization of gold nanoparticles in a size-controlled manner. The chemical versatility of the MDP design broadens the applicability of this strategy, thereby emerging as a successful alternative for the currently available nanoparticle preparation technologies.
Single-step nanoparticle preparation
Fiber optic sensors
Published Version (Please cite this version)http://dx.doi.org/10.1021/acsami.5b00093
Showing items related by title, author, creator and subject.
One-step synthesis of size-tunable Ag nanoparticles incorporated in electrospun PVA/cyclodextrin nanofibers Celebioglu A.; Aytac Z.; Umu, O. C. O.; Dana, A.; Tekinay, T.; Uyar T. (Pergamon Press, 2014)One-step synthesis of size-tunable silver nanoparticles (Ag-NP) incorporated into electrospun nanofibers was achieved. Initially, in situ reduction of silver salt (AgNO3) to Ag-NP was carried out in aqueous solution of ...
Understanding the plasmonic properties of dewetting formed Ag nanoparticles for large area solar cell applications Günendi, M.C.; Tanyeli I.; Akgüç G.B.; Bek, A.; Turan, R.; Gülseren O. (Optical Society of American (OSA), 2013)The effects of substrates with technological interest for solar cell industry are examined on the plasmonic properties of Ag nanoparticles fabricated by dewetting technique. Both surface matching (boundary element) and ...