Multi-domain short peptide molecules for in situ synthesis and biofunctionalization of gold nanoparticles for integrin-targeted cell uptake

Simple item page
buir.contributor.authorGülsuner, Hilal Ünal
buir.contributor.authorCeylan, Hakan
buir.contributor.authorGüler, Mustafa O.
buir.contributor.authorTekinay, Ayse B.
dc.citation.epage10683en_US
dc.citation.issueNumber20en_US
dc.citation.spage10677en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorGülsuner, Hilal Ünalen_US
dc.contributor.authorCeylan, Hakanen_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.date.accessioned2016-02-08T09:52:39Z
dc.date.available2016-02-08T09:52:39Z
dc.date.issued2015en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractWe describe design and synthesis model of multidomain (modular) peptides (MDPs), which direct a reaction cascade coupling the synthesis and surface functionalization of gold nanoparticles (AuNPs) in a single step. The synthesis is achieved via simple mixing of the aqueous solutions of auric acid and MDPs at room temperature without the addition of any surfactants or toxic intermediate reagents. This method allows facile control over the nanoparticle size between ∼2–15 nm, which opens a practical window for biomedical applications. In contrast to the conventional citrate-mediated methods, peptide-mediated synthesis and stabilization provide increased colloidal stability to AuNPs. As a proof of this concept, we demonstrate active targeting of human breast adenocarcinoma cell line (MCF7) using the one-step-prepared engineered AuNPs. Overall, we propose a single-step, chemically greener, biologically safer method for the synthesis and surface functionalization of gold nanoparticles in a size-controlled manner. The chemical versatility of the MDP design broadens the applicability of this strategy, thereby emerging as a successful alternative for the currently available nanoparticle preparation technologies.en_US
dc.identifier.doi10.1021/acsami.5b00093en_US
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/11693/21892
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acsami.5b00093en_US
dc.source.titleACS Applied Materials and Interfacesen_US
dc.titleMulti-domain short peptide molecules for in situ synthesis and biofunctionalization of gold nanoparticles for integrin-targeted cell uptakeen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Multi-Domain Short Peptide Molecules for in Situ Synthesis and Biofunctionalization of Gold Nanoparticles for Integrin-Targeted Cell Uptake.pdf
Size:
1.9 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download
Collections
Institute of Materials Science and Nanotechnology (UNAM)
Aysel Sabuncu Brain Research Center (BAM)
Nanotechnology Research Center (NANOTAM)