dc.contributor.author | Onen-Bayram, F. E. | en_US |
dc.contributor.author | Durmaz, I. | en_US |
dc.contributor.author | Scherman, D. | en_US |
dc.contributor.author | Herscovici, J. | en_US |
dc.contributor.author | Cetin Atalay, R. | en_US |
dc.date.accessioned | 2016-02-08T09:44:55Z | |
dc.date.available | 2016-02-08T09:44:55Z | |
dc.date.issued | 2012 | en_US |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | http://hdl.handle.net/11693/21334 | |
dc.description.abstract | The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserved. | en_US |
dc.language.iso | English | en_US |
dc.source.title | Bioorganic and Medicinal Chemistry | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.bmc.2012.07.016 | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cancer | en_US |
dc.subject | Caspase-9 | en_US |
dc.subject | Cytotoxic | en_US |
dc.subject | Terminal alkyne | en_US |
dc.subject | Thiazolidine | en_US |
dc.title | A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells | en_US |
dc.type | Article | en_US |
dc.department | Department of Molecular Biology and Genetics | en_US |
dc.citation.spage | 5094 | en_US |
dc.citation.epage | 5102 | en_US |
dc.citation.volumeNumber | 20 | en_US |
dc.citation.issueNumber | 17 | en_US |
dc.identifier.doi | 10.1016/j.bmc.2012.07.016 | en_US |
dc.publisher | Elsevier | en_US |