A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells

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dc.citation.epage5102en_US
dc.citation.issueNumber17en_US
dc.citation.spage5094en_US
dc.citation.volumeNumber20en_US
dc.contributor.authorOnen-Bayram, F. E.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorScherman, D.en_US
dc.contributor.authorHerscovici, J.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.date.accessioned2016-02-08T09:44:55Z
dc.date.available2016-02-08T09:44:55Z
dc.date.issued2012en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.bmc.2012.07.016en_US
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/11693/21334
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.bmc.2012.07.016en_US
dc.source.titleBioorganic and Medicinal Chemistryen_US
dc.subjectApoptosisen_US
dc.subjectCanceren_US
dc.subjectCaspase-9en_US
dc.subjectCytotoxicen_US
dc.subjectTerminal alkyneen_US
dc.subjectThiazolidineen_US
dc.titleA novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cellsen_US
dc.typeArticleen_US
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