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      • Department of Molecular Biology and Genetics
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      A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells

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      Author(s)
      Onen-Bayram, F. E.
      Durmaz, I.
      Scherman, D.
      Herscovici, J.
      Cetin Atalay, R.
      Date
      2012
      Source Title
      Bioorganic and Medicinal Chemistry
      Print ISSN
      0968-0896
      Publisher
      Elsevier
      Volume
      20
      Issue
      17
      Pages
      5094 - 5102
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserved.
      Keywords
      Apoptosis
      Cancer
      Caspase-9
      Cytotoxic
      Terminal alkyne
      Thiazolidine
      Permalink
      http://hdl.handle.net/11693/21334
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.bmc.2012.07.016
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