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      • Graduate Program in Materials Science and Nanotechnology - Master's degree
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      • University Library
      • Bilkent Theses
      • Theses - Graduate Program in Materials Science and Nanotechnology
      • Graduate Program in Materials Science and Nanotechnology - Master's degree
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      Small functional groups presented on peptide nanofibers for determining fate of rat mesenchymal stem cells

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      Embargo Lift Date: 2016-12-18
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      Author
      Yaşa, Öncay
      Advisor
      Tekinay, Ayşe Begüm
      Date
      2014
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Glycosaminoglycans (GAGs) are negatively-charged, unbranched polysaccharides that play important roles in various biological processes and are vital for the regeneration of damaged tissues. Like other natural extracellular matrix components, glycosaminoglycans and proteoglycans show considerable variation in local concentration and chemical composition depending on tissue type. They are found in various connective tissues, including bone, cartilage and fat, and display strong water-binding capacity due to their negative charges. Mechanical characters of GAGs are heavily influenced by the degree and pattern of sulfation, which may greatly alter their viscoelasticity and physiological functions. Variations in GAG sulfation patterns are created principally through extracellular matrix modeling. Due to their extracellular matrix-organizing abilities, glycosaminoglycans are promising biomacromolecules for the design of new bioactive materials for tissue engineering and tissue reconstruction applications. In this study, we functionalized peptide amphiphile molecules with carboxylate and sulfonate groups to develop nanofibrous networks displaying a range of chemical patterns, and evaluated the effect of the chemical groups over the differentiation fate of rat mesenchymal stem cells. We demonstrate that higher sulfonate-to-glucose ratios are associated with adipogenesis, while higher carboxylate-to-glucose ratios resulted in chondrogenic and osteogenic differentiation of the rat mesenchymal stem cells.
      Keywords
      Peptide Nanofibers
      Extracellular Matrix
      Glycosaminoglycans
      Biomimetic
      Mesenchymal Stem Cells
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      http://hdl.handle.net/11693/18353
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      • Graduate Program in Materials Science and Nanotechnology - Master's degree 142
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