Small functional groups presented on peptide nanofibers for determining fate of rat mesenchymal stem cells

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buir.advisorTekinay, Ayşe Begüm
dc.contributor.authorYaşa, Öncay
dc.date.accessioned2016-01-08T20:18:31Z
dc.date.available2016-01-08T20:18:31Z
dc.date.issued2014
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.descriptionAnkara : The Department of Materials Science and Nanotechnology and the Graduate School of Engineering and Science of Bilkent University, 2014.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2014.en_US
dc.descriptionIncludes bibliographical references leaves 88-95.en_US
dc.description.abstractGlycosaminoglycans (GAGs) are negatively-charged, unbranched polysaccharides that play important roles in various biological processes and are vital for the regeneration of damaged tissues. Like other natural extracellular matrix components, glycosaminoglycans and proteoglycans show considerable variation in local concentration and chemical composition depending on tissue type. They are found in various connective tissues, including bone, cartilage and fat, and display strong water-binding capacity due to their negative charges. Mechanical characters of GAGs are heavily influenced by the degree and pattern of sulfation, which may greatly alter their viscoelasticity and physiological functions. Variations in GAG sulfation patterns are created principally through extracellular matrix modeling. Due to their extracellular matrix-organizing abilities, glycosaminoglycans are promising biomacromolecules for the design of new bioactive materials for tissue engineering and tissue reconstruction applications. In this study, we functionalized peptide amphiphile molecules with carboxylate and sulfonate groups to develop nanofibrous networks displaying a range of chemical patterns, and evaluated the effect of the chemical groups over the differentiation fate of rat mesenchymal stem cells. We demonstrate that higher sulfonate-to-glucose ratios are associated with adipogenesis, while higher carboxylate-to-glucose ratios resulted in chondrogenic and osteogenic differentiation of the rat mesenchymal stem cells.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityYaşa, Öncayen_US
dc.embargo.release2016-12-18
dc.format.extentxxii, 95 leaves, illustrationsen_US
dc.identifier.itemidB149309
dc.identifier.urihttp://hdl.handle.net/11693/18353
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeptide Nanofibersen_US
dc.subjectExtracellular Matrixen_US
dc.subjectGlycosaminoglycansen_US
dc.subjectBiomimeticen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subject.lccQH588.S83 Y37 2014en_US
dc.subject.lcshStem cells.en_US
dc.subject.lcshStem cells--Transplantation.en_US
dc.subject.lcshBiochemistry.en_US
dc.titleSmall functional groups presented on peptide nanofibers for determining fate of rat mesenchymal stem cellsen_US
dc.typeThesisen_US
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