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      • Theses - Department of Interior Architecture and Environmental Design
      • Dept.of Interior Architecture and Environmental Design - Master's degree
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      •   BUIR Home
      • University Library
      • Bilkent Theses
      • Theses - Department of Interior Architecture and Environmental Design
      • Dept.of Interior Architecture and Environmental Design - Master's degree
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      Walking patterns in shopping malls : the case of Ankamall

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      Author
      Paykoç, Eda
      Advisor
      Akkaya, Engin U.
      Date
      2013
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Search for new noninvasive methods for diseases has been significant question for years. Therapeutic properties of light are combined with proper chromophore in order to create fundamentals of photodynamic therapy which is a new treatment modality for cancer and other various non-oncological diseases. The method relies on the activation of photosensitizer by using light of certain wavelength and generation of cytotoxic singlet oxygen species in response. Reactive oxygen species kill the targeted tissue within smaller effective diameter through apoptosis/ necrosis mechanism. Through this method, new PDT agents can be proposed and their properties can be tuned by manipulation of other photophysical processes. In this thesis, synthesis, characterization novel water soluble, near IR absorbing Bodipy photosensitizer will be discussed. As opposed to other photosensitizers in literature, this photosensitizer is rationally designed to have singlet oxygen generation capability only in cancer tissue as a result of glutathione triggered activation.
      Keywords
      Bodipy
      photodynamic therapy
      Glutathione
      water soluble
      Permalink
      http://hdl.handle.net/11693/15482
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      • Dept.of Interior Architecture and Environmental Design - Master's degree 151
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