Walking patterns in shopping malls : the case of Ankamall
Author
Paykoç, Eda
Advisor
Akkaya, Engin U.
Date
2013Publisher
Bilkent University
Language
English
Type
ThesisItem Usage Stats
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Abstract
Search for new noninvasive methods for diseases has been significant question
for years. Therapeutic properties of light are combined with proper chromophore
in order to create fundamentals of photodynamic therapy which is a new
treatment modality for cancer and other various non-oncological diseases. The
method relies on the activation of photosensitizer by using light of certain
wavelength and generation of cytotoxic singlet oxygen species in response.
Reactive oxygen species kill the targeted tissue within smaller effective diameter
through apoptosis/ necrosis mechanism. Through this method, new PDT agents
can be proposed and their properties can be tuned by manipulation of other
photophysical processes. In this thesis, synthesis, characterization novel water
soluble, near IR absorbing Bodipy photosensitizer will be discussed. As opposed
to other photosensitizers in literature, this photosensitizer is rationally designed
to have singlet oxygen generation capability only in cancer tissue as a result of
glutathione triggered activation.