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      Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

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      Author
      Atalay, N.
      Unal, Hilal Unal
      Erbil, H. Y.
      Tekinay, Ayse Begum
      Date
      2014
      Source Title
      Colloids and Surfaces B: Biointerfaces
      Print ISSN
      0927-7765
      Publisher
      Elsevier
      Volume
      113
      Pages
      403 - 411
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      The objective of this study is to prepare polymeric surfaces which will adsorb L1210 leukemia cells selectively more than that of healthy human leukocytes in order to develop new treatment options for people with leukemia. Chemically heterogeneous and micropatterned surfaces were formed on round glass slides by dip coating with accompanying phase-separation process where only commercial polymers were used. Surface properties were determined by using optical microscopy, 3D profilometry, SEM and measuring contact angles. Polymer, solvent/nonsolvent types, blend composition and temperature were found to be effective in controlling the dimensions of surface microislands. MTT tests were applied for cell viability performance of these surfaces. Polystyrene/polyethylene-polypropylene blend surfaces were found to show considerable positive selectivity to L1210 leukemia cells where L1210/healthy leukocytes adsorption ratio approached to 9-fold in vitro. Effects of wettability, surface free energy, microisland size geometry on the adsorption performances of L1210/leukocytes pairs are discussed.
      Keywords
      Contact angle
      L1210 leukemia cells
      Leukocytes
      Micropatterning
      Selective cell adhesion
      Permalink
      http://hdl.handle.net/11693/12776
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.colsurfb.2013.09.040
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 183
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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