Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

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buir.contributor.authorUnal, Hilal Unal
buir.contributor.authorTekinay, Ayse Begum
dc.citation.epage411en_US
dc.citation.spage403en_US
dc.citation.volumeNumber113en_US
dc.contributor.authorAtalay, N.en_US
dc.contributor.authorUnal, Hilal Unalen_US
dc.contributor.authorErbil, H. Y.en_US
dc.contributor.authorTekinay, Ayse Begumen_US
dc.date.accessioned2015-07-28T12:02:56Z
dc.date.available2015-07-28T12:02:56Z
dc.date.issued2014en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractThe objective of this study is to prepare polymeric surfaces which will adsorb L1210 leukemia cells selectively more than that of healthy human leukocytes in order to develop new treatment options for people with leukemia. Chemically heterogeneous and micropatterned surfaces were formed on round glass slides by dip coating with accompanying phase-separation process where only commercial polymers were used. Surface properties were determined by using optical microscopy, 3D profilometry, SEM and measuring contact angles. Polymer, solvent/nonsolvent types, blend composition and temperature were found to be effective in controlling the dimensions of surface microislands. MTT tests were applied for cell viability performance of these surfaces. Polystyrene/polyethylene-polypropylene blend surfaces were found to show considerable positive selectivity to L1210 leukemia cells where L1210/healthy leukocytes adsorption ratio approached to 9-fold in vitro. Effects of wettability, surface free energy, microisland size geometry on the adsorption performances of L1210/leukocytes pairs are discussed.en_US
dc.identifier.doi10.1016/j.colsurfb.2013.09.040en_US
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/11693/12776
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.colsurfb.2013.09.040en_US
dc.source.titleColloids and Surfaces B: Biointerfacesen_US
dc.subjectContact angleen_US
dc.subjectL1210 leukemia cellsen_US
dc.subjectLeukocytesen_US
dc.subjectMicropatterningen_US
dc.subjectSelective cell adhesionen_US
dc.titleSelective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blendsen_US
dc.typeArticleen_US
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Institute of Materials Science and Nanotechnology (UNAM)
Aysel Sabuncu Brain Research Center (BAM)