Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl) piperazine derivatives
dc.citation.epage | 8085 | en_US |
dc.citation.issueNumber | 7 | en_US |
dc.citation.spage | 8071 | en_US |
dc.citation.volumeNumber | 13 | en_US |
dc.contributor.author | Yarim, M. | en_US |
dc.contributor.author | Koksal, M. | en_US |
dc.contributor.author | Durmaz, I. | en_US |
dc.contributor.author | Atalay, R. | en_US |
dc.date.accessioned | 2016-02-08T09:45:48Z | |
dc.date.available | 2016-02-08T09:45:48Z | |
dc.date.issued | 2012 | en_US |
dc.department | Department of Molecular Biology and Genetics | en_US |
dc.description.abstract | A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines. © 2012 by the authors; licensee MDPI, Basel, Switzerland. | en_US |
dc.description.provenance | Made available in DSpace on 2016-02-08T09:45:48Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012 | en |
dc.identifier.doi | 10.3390/ijms13078071 | en_US |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | http://hdl.handle.net/11693/21402 | |
dc.language.iso | English | en_US |
dc.publisher | M D P I AG | en_US |
dc.relation.isversionof | 10.3390/ijms13078071 | en_US |
dc.source.title | International Journal of Molecular Sciences | en_US |
dc.subject | 1-(4-chlorobenzhydryl)piperazine derivatives | en_US |
dc.subject | Benzoyl chlorides | en_US |
dc.subject | Cancer | en_US |
dc.subject | Cell proliferation | en_US |
dc.subject | Cytotoxicity | en_US |
dc.title | Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl) piperazine derivatives | en_US |
dc.type | Article | en_US |
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