Cancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl) piperazine derivatives

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dc.citation.epage8085en_US
dc.citation.issueNumber7en_US
dc.citation.spage8071en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorYarim, M.en_US
dc.contributor.authorKoksal, M.en_US
dc.contributor.authorDurmaz, I.en_US
dc.contributor.authorAtalay, R.en_US
dc.date.accessioned2016-02-08T09:45:48Z
dc.date.available2016-02-08T09:45:48Z
dc.date.issued2012en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractA series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines. © 2012 by the authors; licensee MDPI, Basel, Switzerland.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:45:48Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2012en
dc.identifier.doi10.3390/ijms13078071en_US
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/11693/21402
dc.language.isoEnglishen_US
dc.publisherM D P I AGen_US
dc.relation.isversionof10.3390/ijms13078071en_US
dc.source.titleInternational Journal of Molecular Sciencesen_US
dc.subject1-(4-chlorobenzhydryl)piperazine derivativesen_US
dc.subjectBenzoyl chloridesen_US
dc.subjectCanceren_US
dc.subjectCell proliferationen_US
dc.subjectCytotoxicityen_US
dc.titleCancer cell Cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl) piperazine derivativesen_US
dc.typeArticleen_US

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