Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms

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buir.contributor.authorDoğrusöz, Uğur
dc.citation.epage10en_US
dc.citation.issueNumber1en_US
dc.citation.spage1en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorMazein, A.en_US
dc.contributor.authorOstaszewski, M.en_US
dc.contributor.authorKuperstein, I.en_US
dc.contributor.authorWatterson, S.en_US
dc.contributor.authorLe Novère, N.en_US
dc.contributor.authorLefaudeux, D.en_US
dc.contributor.authorDe Meulder, B.en_US
dc.contributor.authorPellet, J.en_US
dc.contributor.authorBalaur, I.en_US
dc.contributor.authorSaqi, M.en_US
dc.contributor.authorNogueira, M. M.en_US
dc.contributor.authorHe, F.en_US
dc.contributor.authorParton, A.en_US
dc.contributor.authorLemonnier, N.en_US
dc.contributor.authorGawron, P.en_US
dc.contributor.authorGebel, S.en_US
dc.contributor.authorHainaut, P.en_US
dc.contributor.authorOllert, M.en_US
dc.contributor.authorDoğrusöz, Uğuren_US
dc.contributor.authorBarillot, E.en_US
dc.contributor.authorZinovyev, A.en_US
dc.contributor.authorSchneider, R.en_US
dc.contributor.authorBalling, R.en_US
dc.contributor.authorAuffray, C.en_US
dc.date.accessioned2019-02-21T16:02:32Z
dc.date.available2019-02-21T16:02:32Z
dc.date.issued2018en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractThe development of computational approaches in systems biology has reached a state of maturity that allows their transition to systems medicine. Despite this progress, intuitive visualisation and context-dependent knowledge representation still present a major bottleneck. In this paper, we describe the Disease Maps Project, an effort towards a community-driven computationally readable comprehensive representation of disease mechanisms. We outline the key principles and the framework required for the success of this initiative, including use of best practices, standards and protocols. We apply a modular approach to ensure efficient sharing and reuse of resources for projects dedicated to specific diseases. Community-wide use of disease maps will accelerate the conduct of biomedical research and lead to new disease ontologies defined from mechanism-based disease endotypes rather than phenotypes.
dc.description.provenanceMade available in DSpace on 2019-02-21T16:02:32Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.description.sponsorshipThis work was supported by the CNRS, University of Luxembourg, Institut Curie and in part through the U-BIOPRED (IMI no. 115010 grant to C.A.) and eTRIKS (IMI no. 115446 grant to C.A., R.B. and R.S.) Consortia funded by the European Union and the European Federation of Pharmaceutical Industry Associations, the Coordinating action for the implementation of systems medicine in Europe (CASyM FP7 grant no. 305333 to C.A. and R.B.), the COLOSYS grant ANR-15-CMED-0001-04, provided by the Agence Nationale de la Recherche under the frame of ERACoSysMed-1, the ERA-Net for Systems Medicine in clinical research and medical practice (to I.K., E.B. and A.Z.). A. P. and S.W. acknowledge a research exchange grant from CASyM.
dc.identifier.doi10.1038/s41540-018-0059-y
dc.identifier.issn2056-7189
dc.identifier.urihttp://hdl.handle.net/11693/50014
dc.language.isoEnglish
dc.publisherNature Publishing Group
dc.relation.isversionofhttps://doi.org/10.1038/s41540-018-0059-y
dc.relation.projectInnovative Medicines Initiative, IMI: 115010 - Agence Nationale de la Recherche, ANR - European Geosciences Union, EGU - Université du Luxembourg - ANR-15-CMED-0001-04 - 115446 - Institut Curie - 305333 - European Federation of Pharmaceutical Industries and Associations, EFPIA - Centre National de la Recherche Scientifique, CNRS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.source.titleNPJ Systems Biology and Applicationsen_US
dc.titleSystems medicine disease maps: community-driven comprehensive representation of disease mechanismsen_US
dc.typeArticleen_US

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