Water-dispersible glycosylated poly(2,5′-thienylene)porphyrin-based nanoparticles for antibacterial photodynamic therapy

buir.contributor.authorKhan, Rehan
buir.contributor.authorÖzkan, Melis
buir.contributor.authorKhaligh, Aisan
buir.contributor.authorTuncel, Dönüş
dc.citation.epage1155en_US
dc.citation.issueNumber5en_US
dc.citation.spage1147en_US
dc.citation.volumeNumber18en_US
dc.contributor.authorKhan, Rehanen_US
dc.contributor.authorÖzkan, Melisen_US
dc.contributor.authorKhaligh, Aisanen_US
dc.contributor.authorTuncel, Dönüşen_US
dc.date.accessioned2020-02-17T06:20:27Z
dc.date.available2020-02-17T06:20:27Z
dc.date.issued2019
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractHere we report the preparation of water-dispersible glycosylated poly(2,5′-thienylene)porphyrin based nanoparticles by a nanoprecipitation method and demonstrate the application of these nanoparticles in antibacterial photodynamic therapy. The diameter of the nanoparticles is in the range of 50–80 nm and the resulting nanoparticles are stable in water without precipitation at least for a month. They have high singlet oxygen efficiency and display light-triggered biocidal activity against both Gram negative bacteria (Escherichia coli, E. coli) and Gram positive bacteria (Bacillus subtilis, B. subtilis). Upon white light irradiation for 10 min with a flux of 22 mW cm−2 of the E. coli suspension incubated with NPs (18 μg mL−1), a killing efficiency of 99% is achieved, whereas in the dark the effect is recorded as only around 8%.en_US
dc.description.provenanceSubmitted by Evrim Ergin (eergin@bilkent.edu.tr) on 2020-02-17T06:20:27Z No. of bitstreams: 1 Water-dispersible_glycosylated_poly_25′-Thienylene_porphyrin-based_nanoparticles_for_antibacterial_photodynamic_therapy.pdf: 2221153 bytes, checksum: 187d0af1e09d1cb6a645985bcb57e416 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-02-17T06:20:27Z (GMT). No. of bitstreams: 1 Water-dispersible_glycosylated_poly_25′-Thienylene_porphyrin-based_nanoparticles_for_antibacterial_photodynamic_therapy.pdf: 2221153 bytes, checksum: 187d0af1e09d1cb6a645985bcb57e416 (MD5) Previous issue date: 2019-02en
dc.identifier.doi10.1039/c8pp00470fen_US
dc.identifier.eissn1474-9092
dc.identifier.issn1474-905X
dc.identifier.urihttp://hdl.handle.net/11693/53376
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://dx.doi.org/10.1039/c8pp00470fen_US
dc.source.titlePhotochemical & Photobiological Sciencesen_US
dc.titleWater-dispersible glycosylated poly(2,5′-thienylene)porphyrin-based nanoparticles for antibacterial photodynamic therapyen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Water_dispersible_glycosylated_poly_25-thienylene_porphyrin_based_nanoparticles_for_antibacterial_photodynamic_therapy.pdf
Size:
2.12 MB
Format:
Adobe Portable Document Format
Description:
View / Download